Better Predicting Advanced Prostate Cancer Outcomes with NaF-PET/CT Scans

Imaging of prostate cancer has been improving by leaps and bounds over the last few years. Current imaging techniques are not sensitive enough to give us an accurate picture of the cancer. This means that we lose predictive abilities and don’t always have adequate information to make the best treatment decisions. It also means, in some situations, that insurance will not always cover what is clearly the best treatment because we lack evidence of the actual disease state to qualify for the FDA label of certain treatments. In a move to develop better, more accurate scanning technology, a recent study [...]

New Markers To Make Better Treatment Decisions For Prostate Cancer

Making treatment decisions once you have been diagnosed with prostate cancer is difficult. Often, it is impossible to accurately and reliably be able to predict the eventual course of the cancer. Prostate cancer, besides being one of the slower growing cancers, is also one of the deadliest. So good, informed decisions are vital. The original standby prognostic markers for prostate cancer are a man’s PSA, the stage of the cancer and their Gleason grade. Given the poor quality of these markers, in the 2000s, more sensitive markers were developed, such as PSA density, % of positive cores, % of cancer [...]

PET/CT Scans More Sensitive Than CT and Bone Scans For Detecting Metastatic Prostate Cancer

According to an article in the Journal of Nuclear Medicine, researchers compared a PET/CT scan using the radiotracer F-18 DCFBC to conventional imaging modalities — an expanded Tc-99m-methylene diphosphonate (MDP) bone scan and contrast-enhanced CT of the chest, abdomen and pelvis — to detect prostate-specific membrane antigen (PSMA), which is associated with prostate cancer metastases. In a study of 17 men the researchers found that the F-18 DCFBC PET scans were able to detect a larger number of prostate cancer lesions than the other imaging modalities. The researchers found 592 positive lesions compared to 520 identified by the other methods. [...]

CTC Heterogeneity Predicts Prostate Cancer Drug Sensitivity

This afternoon I am off to the American Society for Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) in San Francisco. There has already been some information leaking to the media about some of the presentations that will be going on at the conference. One such “leak” is about  findings from Memorial Sloan Kettering Cancer Center and Epic Sciences who will be reporting that they have found that greater diversity among circulating tumor cells (CTCs) in the blood (heterogeneity) of men with advanced prostate cancer predicts not only shorter overall survival, but also the development of resistance to anti-androgen therapies. However, [...]

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