Is Alkaline Phosphatase A Bio-Marker To Predict PSA Decline And Clinical Benefit From Abiraterone Acetate in Bone Metastatic Castration Resistant Prostate Cancer

Again and again I have mentioned the huge need we have for the development of reliable bio-markers. Reliable bio-markers will allow us to know which men will respond positively to a treatment (also those who will not) and when a treatment is still effective (also when it no longer is effective). These biomarkers really don’t exist, so a lot of clinical decision-making is based upon the experience and gut feeling of our doctors. This type of decision-making is not adequate in today’s world of multiple treatment options, especially when many of the treatments can foster resistance to other available treatments. [...]

Flawed Study Shows A Sharp Rise in Advanced Prostate Cancer

Yesterday’s post described research performed at Northwestern University that found a sharp increase in the number of men diagnosed with advanced aggressive prostate cancer between 2004 and 2013. The research interpretation raised the possibility that the United States Preventive Task Force (USPTF) decision to recommend against the use of the PSA test for prostate cancer screening was to blame for this high increase of aggressive disease. A number of news media pick up the story as well as this blog. Additional scientific commentary has questioned the research techniques used to draw this conclusion. According the American Cancer Society the study [...]

Reporting A Concerning Increase In The Number Of Men Diagnosed With Advanced Prostate Cancer

According to information from a published report from the Tuesday, July 19, 2016 edition of HealthDay News, there has been an explosion of new cases of advanced prostate cancer in the United States. They reported on a study using data on nearly 800,000 men listed in the National Cancer Data Base who had been diagnosed with prostate cancer between 2004 and 2013.   They concluded that new cases of advanced prostate cancer have skyrocketed by 72 percent in the past decade. They reported that the biggest increase was in the age group of men between 55 to 69 years. They point [...]

Standardizing PSA Definition of Biochemical Recurrence after Radical Prostatectomy

There are multiple definitions of biochemical recurrence for prostate cancer treatment post surgery. This causes confusion both within the patient community and the medical community. It would be very helpful if we could standardize a simple measure, PSA as the biomarker for a biochemical recurrence. Standardization post surgery would give us a better way to decide at what point additional treatment would most benefit a man with recurrent prostate cancer. To accomplish this goal researchers reviewed the long-term prostatectomy outcomes to assess the most appropriate prostate specific antigen cut point that predicts future disease progression. The study was large, including [...]

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