From Active Surveillance to Metastatic Prostate Cancer – Know The Risks As You Decide

Historically, too many men were haphazardly treated for prostate cancer. Happily, the incidents of over treatment have been declining and the general acceptance of Active Surveillance has emerged as the preferred management strategy for men with very low–risk prostate cancer. However, There is still too few high-quality comparative effectiveness studies evaluating the incremental risks associated with or active surveillance. In a prospective study published in the Journal of Urology, researchers reported the risk men face of developing metastatic disease. They evaluated a large, mature, active surveillance cohort. It was reported that, at median follow-up of 6 years, 3.1% of men [...]

Positive Findings In Pelvic MRIs In Relapsed Prostate Cancer After Failed Radical Prostatectomy

There has been a lot of conversation about the role of and the use of multi-parametric MRIs in the initial diagnostic stages of prostate cancer, but little is known about its potential clinical application in the use of early salvage radiotherapy after failed radical prostatectomy. In a study to exam the potential of multi-parametric MRIs in men experiencing surgical failure as defined by a rising PSA post surgery, researchers reviewed the records and MRI studies of 70 men with rising PSA scores post surgery. They evaluated the incidence and location of recurrence based on pelvic multi-parametric MRI findings and to [...]

What Are The Negative Prognostic Factors You Should Know When You Have A Biochemical Prostate Cancer Occurrence

Knowing the negative prognostic factors for successful treatment when you have a   a biochemical recurrence (PSA only) of your prostate cancer is important. These factors can help you make your treatment decisions because they assist you in evaluating your possible clinical outcome. In a single institutional review of  negative prognostic outcomes of salvage radiotherapy in men who had a radical prostatectomy as their primary treatment between September 1995 and December 2011 researcher were able to define the negative prognostic factors. In their research cohort of 149 men who had three-dimensional conformal radiotherapy or intensity-modulated radiotherapy to treat their recurrence with [...]

Measuring the Efficacy of Salvage Radiation With and Without ADT *

A small study from one hospital in Norway has suggested that PSA doubling times after surgery may predict the value of salvage radiation therapy alone as a second line form of therapy. Servoll et al carried out a small retrospective analysis of data derived from 76 men treated by salvage external beam radiation therapy (EBRT) at a single Norwegian hospital between 1987 and 2010. All of the men in the subject pool had a biochemical recurrence after a failed radical prostatectomy prior to receiving the radiotherapy. None of these men received adjuvant or neoadjuvant androgen deprivation therapy (ADT) in conjunction [...]