Bones and Prostate Cancer

/Bones and Prostate Cancer

Levels of Serum Alkaline Phosphatase Reflect Negative Prostate Cancer Bone Activity

Not often discussed, but a valuable measure of prostate cancer bone activity is serum (in the blood) alkaline phosphatase. It is a normal enzyme produced naturally by the body. Everyone produces some of this enzyme regardless of his or her state of health, gender, or age. The tissues that produce the most alkaline phosphatase are the bones and liver.  When prostate cancer spreads to the bones, its most common target, the cancer breaks down the bones and leaks alkaline phosphatase into the blood where it can be measured by a simple and inexpensive blood test. Measuring the levels of alkaline phosphatase in [...]

Transdermal Estrogen Is Good For Hot Flash Mitigation and For Hormone Therapy (ADT)

Yesterday's post about the use of transdermal estrogen patches as an alternative to LHRHa drugs  elicited a question on the Malecare Health Unlocked Advanced Prostate Cancer Online Support Group.  The question raised, or I should say the comment made was that estrogen is used for the purposes of hot flash mitigation and the use of estrogen as an ADT drug was called into question.  This is true, estrogen is sometimes used to mitigate hot flashes, but it is also sometimes used as a first line ADT treatment itself. Originally ADT was accomplished by surgery or the oral use of estrogens [...]

Comparison Evaluating Bone Mineral Density Changes in Advanced Prostate Cancer: Luteinising Hormone-releasing Hormone Agonists Versus Transdermal Oestradiol

The current standard hormone therapy (ADT) for men with advanced prostate cancer is a class of drugs called Luteinising hormone-releasing hormone agonists (LHRHa). These drugs reduce serum oestradiol as well as testosterone, causing bone mineral density (BMD) loss as a side effect of the ADT. Using transdermal (skin patches) oestradiol is a potential alternative to LHRHa because it doesn’t have the same negative influence on bone density while still being able to castrate a man. In an attempt to compare bone mineral density (BMD) changes in men receiving either LHRHa or oestradiol patches (OP) researchers compared the BMD effects of [...]

How Quickly You Might Die From Advanced Prostate Cancer Depends On What Organs Are Involved

Researchers at the Duke Cancer Institute along with other cancer centers, in the largest analysis of its kind have found that the organ site where prostate cancer spreads has a direct impact on a man’s survival. They found that men with lymph-only metastasis statistically have the longest overall survival possibility, while those with liver involvement the worst. Men with lung and bone metastasis fall in the middle of these two groups. It has been generally assumed, based on smaller studies, ”that the site of metastasis in prostate cancer affects survival, but prevalence rates in organ sites were small, so it [...]