Clinical Trials & Research

/Clinical Trials & Research

Can A Low Carb Diet Affect the Side Effects of Hormone Therapy (ADT)?

Dr. Steve Freedland, from Cedar Sinai conducted a controlled, randomized clinical study that evaluated the efficacy of an extremely low carbohydrate diet on the side effects of hormone therapy (ADT).   The study showed that an extreme diet has a positive impact on many of the side negative effects as well as causing significant weight loss that probably has many other additional positive health effects. An interview with Dr. Freedland is available at: as well as another interview with him that basically repeating the findings already mentioned at: urologytimes.modernmedicine... Briefly, summing up some of his findings he reported that: "In [...]

Expanding the Role of Radium-223 (Xofigo)

One of the newer drugs and one that has recently had great air play is the bone targeting radiopharmaceutical drug radium-223 or Xofigo. Currently, it is approved for men with castrate resistant prostate cancer with bone metastases. The problem is that currently Xofigo is only approved for one round of treatment using 6 monthly infusions. Given its success, the question we are now asking is if additional dosing would provide an even better result? Bayer Pharmaceuticals currently has a number of clinical trials examining this type of question. In one of the small prospective studies looking at the impact of [...]

Efficacy of Enzalutamide in Castrate-Resistant Prostate Cancer in Men with Visceral Metastases

We know that men with metastatic castration-resistant prostate cancer (mCRPC) and visceral metastases have a worse prognosis than those with non-visceral metastases. The important question we need to understand is what, of our currently available treatments, might be effective for this more aggressive and deadly type of prostate cancer? Results of the phase 3 AFFIRM clinical trial have demonstrated that treatment with the androgen receptor inhibitor enzalutamide (Xtandi) resulted in significant improvements in outcomes for men with mCRPC. This blog post discusses the efficacy of enzalutamide among men from the AFFIRM trial who had visceral disease. Men who were in [...]

Clinical Trial Results, Both Negative and Positive, Will Now Have To Be Reported In A Timely Manner!

Clinical trials are the main stream of developing and then getting necessary approvals for drugs to be able to make it to market. Drug companies, like every other company and every individual want only to have successes. We all also have egos and when there is a failure we often prefer to bury that information so that it doesn’t reflect poorly on us. This is human nature and it can serve as an economic driver for drug companies. When clinical trials do fail this information is most often not reported. Also, sometimes when trials do succeed the information, for various [...]

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