Liver Metastases

//Liver Metastases

Efficacy of Enzalutamide in Castrate-Resistant Prostate Cancer in Men with Visceral Metastases

We know that men with metastatic castration-resistant prostate cancer (mCRPC) and visceral metastases have a worse prognosis than those with non-visceral metastases. The important question we need to understand is what, of our currently available treatments, might be effective for this more aggressive and deadly type of prostate cancer? Results of the phase 3 AFFIRM clinical trial have demonstrated that treatment with the androgen receptor inhibitor enzalutamide (Xtandi) resulted in significant improvements in outcomes for men with mCRPC. This blog post discusses the efficacy of enzalutamide among men from the AFFIRM trial who had visceral disease. Men who were in [...]

How Quickly You Might Die From Advanced Prostate Cancer Depends On What Organs Are Involved

Researchers at the Duke Cancer Institute along with other cancer centers, in the largest analysis of its kind have found that the organ site where prostate cancer spreads has a direct impact on a man’s survival. They found that men with lymph-only metastasis statistically have the longest overall survival possibility, while those with liver involvement the worst. Men with lung and bone metastasis fall in the middle of these two groups. It has been generally assumed, based on smaller studies, ”that the site of metastasis in prostate cancer affects survival, but prevalence rates in organ sites were small, so it [...]

Liver Metastases and ECF – A Possible Treatment In A Not Good Situation

Liver metastases are uncommon in men with castrate resistant prostate cancer (CRPC). Having liver metastases is associated with more serious disease and shorter survival. How to treat men with liver metastases is still not very clear. It is felt that more active treatment might benefit these men. A standard regimen for treating gastric cancer is Epirubicin, Cisplatin and Flurouracil (ECF). This regimen has been reported to also have a response in CRPC in men with liver metastases. In a research survey of the use of ECF in CRPC was evaluated with the primary objective of determining its anti-tumor activity in [...]

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