Drugs & Treatments

/Drugs & Treatments

prostate cancer drugs and treatments that are available

Enzalutamide Prescribing Info Expanded – Probably Having No Effect On Men with Advanced Prostate Cancer

The latest update on enzalutamide (Xtandi) is that it now has a new, expanded FDA label. The new label confirms the clinical trial (TERRAIN) results showing that Xtandi is a superior drug to Casodex (bicalutamide). The trial compared enzalutamide with bicalutamide among men with metastatic castration-resistant prostate cancer (CRPC). To be specific, the updated product label now includes data that shows enzalutamide reduces the risk of radiographic progression or death by 40% vs. bicalutamide. Median radiographic progression-free survival was 19.5 months with enzalutamide compared with 13.4 months with bicalutamide. Steven Benner, MD, senior vice president, therapeutic area head for oncology [...]

By | October 26th, 2016|Casodex, enzalutamide, Uncategorized, Xtandi|0 Comments

Expanding the Role of Radium-223 (Xofigo)

One of the newer drugs and one that has recently had great air play is the bone targeting radiopharmaceutical drug radium-223 or Xofigo. Currently, it is approved for men with castrate resistant prostate cancer with bone metastases. The problem is that currently Xofigo is only approved for one round of treatment using 6 monthly infusions. Given its success, the question we are now asking is if additional dosing would provide an even better result? Bayer Pharmaceuticals currently has a number of clinical trials examining this type of question. In one of the small prospective studies looking at the impact of [...]

A Brief Update of the Current Landscape of Bone Targeted Therapies for Prostate Cancer

Prostate cancer tends to metastasize to bones as opposed to soft tissue and other organs.   We have no idea why it does have a preference for bone, but it does. Developing bone metastases in prostrate cancer is a very strong negative prognostic indicator. Prostate cancer’s tendency to favor bone over soft tissue causes significant morbidity and mortality for men. Bone metastasis has a major impact on quality of life and longevity for men with prostate cancer and it needs to be aggressively treated. Because of this, prostate cancer survivors need to focus on drugs that slow down or interfere with [...]

Degarelix or Leuprolide – Today’s Question Explored

There are many different types of drugs used for hormone therapy in the treatment of prostate cancer. One of the newer classes of drugs include the GnRH antagonists. Degarelix (aka Firmagon) is the one drug in this class that is currently approved for prostate cancer. Degarelix, like the other hormone therapy drugs, was developed to suppress testosterone. What makes this class of drugs different is that it also avoids the flare phenomenon that is observed with the GnRH agonists like Lupron. The flare phenomenon, where the body initially pumps out additional levels of testosterone in response to the GnRH agonist [...]

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