denosumab – Xgeva

A Brief Update of the Current Landscape of Bone Targeted Therapies for Prostate Cancer

Prostate cancer tends to metastasize to bones as opposed to soft tissue and other organs.   We have no idea why it does have a preference for bone, but it does. Developing bone metastases in prostrate cancer is a very strong negative prognostic indicator. Prostate cancer’s tendency to favor bone over soft tissue causes significant morbidity and mortality for men. Bone metastasis has a major impact on quality of life and longevity for men with prostate cancer and it needs to be aggressively treated. Because of this, prostate cancer survivors need to focus on drugs that slow down or interfere with [...]

What You Need to Know About Xgeva or Denosumab

Xgeva, also known as denosumab, is an injectable medication (injected once a month subcutaneously under the skin in the doctor’s office) that is used to prevent bone fractures and spinal cord compression caused by bone metastases in breast and prostate cancer survivors. Solid tumors in the bone, which is a common site for individuals with breast and prostate cancer, can cause significant complications. Potential complications of these tumors include bone fractures and spinal cord compression that could lead to the need for radiation treatment or surgery to the involved bones as well as possible paralysis. Xgeva is used to prevent [...]

Skeletal Events and the Treatment of Men with Advanced Prostate Cancer

Many of our doctors are constantly vigilant about our developing skeletal related issues.   Having advanced prostate cancer and receiving treatment for this disease increases our odds of developing skeletal issues which affect both our quality of life and our mortality. Drugs like denosumab (Xgeva) and zoledronic acid (Zometa) are important in delaying the onset of skeletal related event complications, however neither of these drugs improve survival nor delay mortality. They both are beneficial and have an important role in delaying the complications of bone metastases in men with metastatic castrate resistant prostate cancer (mCRPC). The two new “super” ADT drugs [...]

Make Sure You Receive the Correct IV Treatment, Injection and Dosage

It is vital that you take an active role in making sure that you are going to receive the correct IV treatment and injections. Mistakes do happen, protect yourself. Make sure that you personally double check to confirm you're receiving the correct treatment. Don't sit back and rely on another person, errors do occur and you will be the one to suffer. 1. When you see your oncologist ask for a list of the drugs you will be receiving at your next infusion. Bring this list with you to the infusion center. 2. At the infusion center the certified oncology [...]

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