Chemo Therapy

Men With Castrate Resistant Prostate Cancer Can Experience A PSA Flare When Starting Docetaxel Chemotherapy

The PSA flare phenomenon when first starting chemotherapy with docetaxel has been noted by many clinicians. To evaluate this flare in men with castrate resistant prostate cancer treated with docetaxel, researchers retrospectively evaluated the charts of 56 men who received docetaxel-based chemotherapy in three different centers from August 1999 to August 2007. They found that there was an immediate PSA decline equal to or more than 50% in 23 (41%) of the men, PSA stabilization or PSA decline less than 50% in 16 (29%) men and PSA progression in nine men (16%). They also found that there was also a [...]

The Impact of Co-morbidity on Outcomes in Men with Advanced Prostate Cancer Treated with Chemotherapy (Docetaxel)

Side effects, or what are known as co-morbidities, often discourage men who have metastatic prostate cancer from continuing with chemotherapy (docetaxel). The question often asked is there a relationship between having side effects and the ultimate efficacy of the chemotherapy? In other words does having side effects have an effect on overall survival? To answer this question researchers performed a population-based outcome study. In the study men with mCRPC were treated with docetaxel at the Institute of Oncology Ljubljana between 2005 and 2012. Standard validated scales were used to assess each man’s co-morbidity. The association between co-morbidity and overall survival [...]

Our New Therapies and the Development of Cross Resistance to these Drugs

Men with metastatic castrate resistant prostate cancer (mCRPC) have become fortunate over the last few years as there we now have a number of new drugs available which can extend our life and can also have some palliative effects. However, as we have more treatments being approved, we find that we are faced with a significant issue, how to sequence these drugs. The major problem causing this sequencing crisis is cross-resistance. The use of each of any of these drugs limits the use of the another drug in men who have failed the original prior therapy. This problem, cross-resistance, is [...]

Make Sure You Receive the Correct IV Treatment, Injection and Dosage

It is vital that you take an active role in making sure that you are going to receive the correct IV treatment and injections. Mistakes do happen, protect yourself. Make sure that you personally double check to confirm you're receiving the correct treatment. Don't sit back and rely on another person, errors do occur and you will be the one to suffer. 1. When you see your oncologist ask for a list of the drugs you will be receiving at your next infusion. Bring this list with you to the infusion center. 2. At the infusion center the certified oncology [...]

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