Androgan Receptor Inhibitor

///Androgan Receptor Inhibitor

Enzalutamide Prescribing Info Includes New Information

Enzalutamide (Xtandi) has a new, expanded FDA label. The new label conforms with the clinical trial (TERRAIN) results that Xtandi is a superior drug to Casodex (bicalutamide) for men with metastatic castration-resistant prostate cancer (CRPC). The updated product label shows enzalutamide reduces the risk of radiographic progression or death by 40% vs. bicalutamide. Median radiographic progression-free survival was 19.5 months with enzalutamide compared with 13.4 months with bicalutamide. Steven Benner, MD, senior vice president, therapeutic area head for oncology development, Astellas, said in a statement, "The addition of data from the TERRAIN trial continues to build the body of evidence [...]

By | October 26th, 2016|Casodex, enzalutamide, Uncategorized, Xtandi|0 Comments

Increased Risks for Cardiovascular Events in Men with Prostate Cancer on GnRH Agonist Therapy

Traditional hormone therapy usually consists of two types of drugs; GnRH agonists (like Lupron and Zoladex) and antiandrogens (Casodex). Although they both are drugs that manipulate the hormone system their modes of action are different. GnRH agonists block the production of the male hormone testosterone while the antiandrogen drug blocks the ability of the prostate cancer to absorb any testosterone generated by the body. Antiandrogens do not inhibit the actual production of testosterone! We are aware that ADT does increase a man’s risk for cardiovascular events and mortality. The question is which of these drugs might be responsible for the [...]

Coming Back to Continue the Blog and New Data Disclosed on Enzalutamide at the Plenary Session at the 2015 European Association of Urology Congress

Before I get into the meat of today’s post about enzalutamide, I want to briefly make some personal comments about my absence from this blog. As I had mentioned I have been diagnosed with a fifth primary cancer, appendiceal cancer. It is a rare cancer, which required my having to remove my appendix, a piece of my right colon, have an exploratory of my entire peritoneal sack and then what is called HIPEC chemotherapy. The surgery and chemotherapy were rough and came with an extended recovery. I am now at the point in my recovery that I am feeling able [...]

Degarelix Monotherapy vs. Luteinizing Hormone-Releasing Hormone Agonists Plus Antiandrogen Flare Protection For Men With Advanced Prostate Cancer *

There are a number of different flavors of hormone therapy (ADT) used to treat advanced prostate cancer. However, they could be summed up and put into two different categories. 1- The use of luteinizing hormone-releasing hormone (LHRH) agonist therapy (drugs like Lupron and Zoladex) along with short term antiandrogen (AA) flare protection 2- Degarelix, a gonadotrophin-releasing hormone antagonist which does not require the use an antiandrogen (AA) flare protection drug because it does not cause a surge in testosterone levels. In a research study where individual patient data from two phase III trials had been pooled to compare the one [...]

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