estrogen patches

Transdermal Estrogen Is Good For Hot Flash Mitigation and For Hormone Therapy (ADT)

Yesterday's post about the use of transdermal estrogen patches as an alternative to LHRHa drugs  elicited a question on the Malecare Health Unlocked Advanced Prostate Cancer Online Support Group.  The question raised, or I should say the comment made was that estrogen is used for the purposes of hot flash mitigation and the use of estrogen as an ADT drug was called into question.  This is true, estrogen is sometimes used to mitigate hot flashes, but it is also sometimes used as a first line ADT treatment itself. Originally ADT was accomplished by surgery or the oral use of estrogens [...]

Comparison Evaluating Bone Mineral Density Changes in Advanced Prostate Cancer: Luteinising Hormone-releasing Hormone Agonists Versus Transdermal Oestradiol

The current standard hormone therapy (ADT) for men with advanced prostate cancer is a class of drugs called Luteinising hormone-releasing hormone agonists (LHRHa). These drugs reduce serum oestradiol as well as testosterone, causing bone mineral density (BMD) loss as a side effect of the ADT. Using transdermal (skin patches) oestradiol is a potential alternative to LHRHa because it doesn’t have the same negative influence on bone density while still being able to castrate a man. In an attempt to compare bone mineral density (BMD) changes in men receiving either LHRHa or oestradiol patches (OP) researchers compared the BMD effects of [...]

The Well Reviewed Guide to Advanced Prostate Cancer (A Survivor Perspective) Has Been Updated and is Now Available for a free Download

Somehow I have been negligent and not let people know that I have written and posted a major update of my “Guide to Advanced Prostate Cancer.” As in the past, it is available as a free download from the Malecare web site. Helping me to update the book was prostate cancer survivor Craig Pynn and my own caretaker, Wendy Lebowitz. Anyone reading the first edition will be surprised when you see how many changes and updates this edition has included. It now has a very extensive conversation about living in the world as a cancer survivor as well as more [...]

Xofigo – Designed to be Used with the Best Standard of Care Treatments

Most of the newly approved drugs and treatments for men with advanced prostate cancer are designed and approved to be used independently of other advanced prostate cancer treatments, other than with the continuation of standard androgen deprivation therapy (ADT). The newly approved drug, Xofigo, is different. It has been designed to supplement, or actually go along with what is referred to as the Best Standard of Care. The phase III clinical trial named the ALSYMPCA was the trial that led to the FDA approval of Xofigo. It was a randomized, double-blind, placebo-controlled international study of the use of Xofigo with [...]

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