Radiation

Belfast Clinical Trial Combining Two Radio-Therapies For Men With Advanced Prostate Cancer

Researchers at Queen’s University in Belfast along with the Belfast Trust are conducting a clinical trial evaluating the combination of two radiotherapy treatments, Radium 223 and Pelvic Radiation using Volumetric Modulated Arc Therapy (VMAT) in men with bone positive advanced prostate cancer. The trial, being called ADRRAD trial, involves combining androgen deprivation therapy (ADT) along with the two radio-therapies. Treatment is expected to last about 18 months. VMAT is an externally delivered type of radiotherapy that manipulates radiation beams to adapt to the shape of the tumor, delivering a more precise dose of radiation and limiting damage to surrounding tissue. Radium 223 is [...]

Side Effects and Toxicity in a Multi-modality Approach Post Radical Prostatectomy with Radiation and ADT

The optimal use and timing of secondary therapy after radical prostatectomy remains controversial despite some new findings supporting the advantages of using aggressive combined secondary therapies was presented at the most recent ASCO GU conference in San Francisco. There are limited data on the patient-reported outcomes following multimodality therapy. Given the move towards increasing combination radiation and hormone therapy post surgery we need to have a better understanding of the possible side effects of this type of treatment modality. Long-term urinary continence and the quality of life as effected by the combined therapies are two of the side effects recently [...]

The Benefit of Using Local Prostate Cancer Therapy for Men with Lymph Node Positive Disease

In an issue of ONCOLOGY, there was a review of the literature provides us with a comprehensive review of the limited literature on management of men with prostate cancer who have pelvic lymph node involvement but no known distant metastatic disease at diagnosis. Common folklore has been that these men, with limited pelvic lymph node involvement, are considered “incurable” and managed solely with androgen deprivation therapy. However, there are several reasons to consider local treatment of men with lymph node positive prostate cancer with prostatectomy, radiation therapy, or both prostatectomy and radiation. Based on the literature we need to change [...]

Can Radiotherapy (Radiation) for the Primary Tumors Benefit Men With Prostate CancerWith Distant Metastasis at Initial Diagnosis?

The common belief is that if you are diagnosed with prostate cancer that has already developed metastases only a systemic treatment will provide a life extending benefit. In other cancers it has been shown that the treatment of the primary tumor improves survival (tumor debulking). To find out if, in fact radiotherapy treatment of the primary tumor in prostate cancer with distant metastasis would provide a similar positive benefit, researchers evaluated the efficacy and toxicity of radiotherapy of the primary tumor in prostate cancer in men with metastasis. The study included 140 men with metastatic prostate cancer at initial diagnosis. [...]