salvage therapy

Salvage Radical Prostatectomy Improves Long Term Survival in Men with Radiation Recurrent Prostate Cancer

A retrospective study, using the SEER Date, a U.S. national database, analyzed data from men diagnosed with prostate cancer and found that salvage radical prostatectomy (SRP) improved the long-term survival in men whose cancer has returned after receiving radiation therapy. We know that approximately 30% of men who have radiation therapy as their primary therapy will have a recurrence of their prostate cancer within 5 years of completing the radiation. The researchers from the University of Missouri School of Medicine identified men with prostate cancer who underwent surgery after radiation. They identified and analyzed the overall and cancer-specific survival outcomes in 364 of these men who underwent salvage [...]

Positive Findings In Pelvic MRIs In Relapsed Prostate Cancer After Failed Radical Prostatectomy

There has been a lot of conversation about the role of and the use of multi-parametric MRIs in the initial diagnostic stages of prostate cancer, but little is known about its potential clinical application in the use of early salvage radiotherapy after failed radical prostatectomy. In a study to exam the potential of multi-parametric MRIs in men experiencing surgical failure as defined by a rising PSA post surgery, researchers reviewed the records and MRI studies of 70 men with rising PSA scores post surgery. They evaluated the incidence and location of recurrence based on pelvic multi-parametric MRI findings and to [...]

Comparing the Morbidity of HIFU to CYRO After Failed Radiation Therapy

Currently, there are a number of different treatments used to treat recurrent prostate cancer when the primary treatment had radiation has failed. In this situation surgery is considered very difficult and can only be successfully performed by an experienced surgeon, so alternative treatments are often considered. Long-term data about the success of these alternative treatments has not yet matured, however we do have some insight into the immediate morbidities caused by some of them. A group of researchers compared the morbidity of whole gland salvage ablation using cryotherapy (CRYO) as well as high-intensity focused ultrasound (HIFU) for radio recurrent prostate [...]

Lack of PSA Decline as an Independent Predictor of Biochemical Failure Post Salvage Radiation Therapy

It would be of great advantage to us if we were able to improve the early detection of responders to salvage external beam radiotherapy (RT) after failed radical prostatectomy (RP). Early detection would allow us to make earlier treatment decisions which should provide for better results. In an attempt to better improve our understanding of early detection, between 2002 and 2007, at a single institution, 136 consecutive men received salvage radiation treatment (RT) to a dose of 66Gy without androgen-deprivation therapy (ADT) aftera prostatectomy (surgery) for a rising prostate-specific antigen (PSA) level. PSA measurements were systematically performed before radiation therapy [...]

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