Repurposing Drugs

//Repurposing Drugs

Our New Therapies and the Development of Cross Resistance to these Drugs

Men with metastatic castrate resistant prostate cancer (mCRPC) have become fortunate over the last few years as there we now have a number of new drugs available which can extend our life and can also have some palliative effects. However, as we have more treatments being approved, we find that we are faced with a significant issue, how to sequence these drugs. The major problem causing this sequencing crisis is cross-resistance. The use of each of any of these drugs limits the use of the another drug in men who have failed the original prior therapy. This problem, cross-resistance, is [...]

Repurposing Another Anti-fungal Drug As A Potential Prostate Cancer Treatment

There is a very interesting international project called Repurposing Drugs in Oncology (ReDO). ReDO is an international collaboration of cancer researchers searching to identify common, inexpensive medications, which may represent an untapped source of novel therapies for cancer. These drugs not only could be used as an alternative to some of our current treatments, but their general availability and minimal cost could make more and better treatments available to people with less economic resources. My last post "The Latest Information On The Role Of Metformin Therapy In The Treatment Of Prostate Cancer" is an example of one possible drug that [...]

The Latest Information On The Role Of Metformin Therapy In The Treatment Of Prostate Cancer

There have been prior studies that have shown that the generic and inexpensive drug Metformin (used to treat diabetes) could be repurposed and used to decrease the risk of developing prostate cancer as well as to treat prostate cancer. Previous studies suggested that metformin is associated with decreased risk of cancer; however, results specifically addressing the potential association with prostate cancer were limited and contradictory. In a recent literature review using the databases of PubMed and Embase prior to January 2014 the association between metformin and the incidence, mortality and recurrence of prostate cancer was evaluated by performing a meta-analysis. [...]

By | April 17th, 2015|Advanced Prostate Cancer, Repurposing Drugs, Research|0 Comments