Sequencing Therapies

//Sequencing Therapies

Xtandi In Combination with Zytiga Is Not Better Than Either Drug Alone

Often I have heard people ask why if one drug is effective we shouldn’t simply take two or three at the same time? The answer is simple, because we don’t know if combining multiple drugs will make any difference to a man’s survival. The only way we can be sure is with good evidence. Good evidence requires, in the case of drugs, doing a clinical trial to see if a certain type of combination will be beneficial. In such a late-stage clinical trial designed to see if Xtandi in addition to Zytiga along with a steroid worked any better than [...]

Side Effects and Toxicity in a Multi-modality Approach Post Radical Prostatectomy with Radiation and ADT

The optimal use and timing of secondary therapy after radical prostatectomy remains controversial despite some new findings supporting the advantages of using aggressive combined secondary therapies was presented at the most recent ASCO GU conference in San Francisco. There are limited data on the patient-reported outcomes following multimodality therapy. Given the move towards increasing combination radiation and hormone therapy post surgery we need to have a better understanding of the possible side effects of this type of treatment modality. Long-term urinary continence and the quality of life as effected by the combined therapies are two of the side effects recently [...]

Using Low Dose Prednisone in First-Line Docetaxel Treatment Improves The Quality of Life (QoL) For Men With Prostate Cancer

Clinical trials are used to both demonstrate that a drug or treatment has efficacy (extends life or improves the quality of life). They also are used as the vehicle to obtain approval from the governmental body responsible for monitoring and approving their use. How the trial is set up will directly dictate the eventual approved label (the approved dose as well as any additional drugs or treatments to be administered along side the investigational drug, etc.). This doesn’t necessarily mean that the label is actually the best option for use as other untested doses or co-administered drugs could still be [...]

Our New Therapies and the Development of Cross Resistance to these Drugs

Men with metastatic castrate resistant prostate cancer (mCRPC) have become fortunate over the last few years as there we now have a number of new drugs available which can extend our life and can also have some palliative effects. However, as we have more treatments being approved, we find that we are faced with a significant issue, how to sequence these drugs. The major problem causing this sequencing crisis is cross-resistance. The use of each of any of these drugs limits the use of the another drug in men who have failed the original prior therapy. This problem, cross-resistance, is [...]

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