REVIEW – Statins Boost Abiraterone (Zytiga) Activity in Prostate Cancer

Another piece of information from the recent ASCO GU conference in San Francisco Researchers have found that adding statin drugs may prolong the sensitivity of abiraterone acetate (Zytiga) in men with castration-resistant prostate cancer (CRPC) To assess the effect of statins on abiraterone therapy, Dr Harshman, of the Lank Center for Genitourinary Oncology at Dana-Farber Cancer Institute, in Boston, Massachusetts and colleagues conducted a retrospective analysis of 224 men, drawn from the institution's database, treated with abiraterone for CRPC. Ninety six percent (96%) of the men had metastatic disease at the time they began treatment with abiraterone; 26% had received [...]

On Hormone Therapy – To Statin Or Not, That Is The Question

JAMA Oncology has published a new study that suggests that adding a statin drug at the initiation of hormone therapy (ADT) to the treatment protocol for a man with progressive, hormone-sensitive prostate cancer may significantly impact their actual time to disease progression (TTP). Historically, we know Statin use has been associated with improved prostate cancer outcomes. It is believed that the biology behind the positive effect of statin drugs is directly related to the fact that Dehydroepiandrosterone sulfate (DHEAS) is a precursor of testosterone (which feeds prostate cancer) and a substrate for SLCO2B1, an organic anionic transporter (moving substances into [...]

Statins Are Not Necessarily The Best Alternative To Control Cholesterol & Prostate Cancer Progression

On April 8th I post on this blog an article called The Cholesterol In Your Diet Might Be Causing Your Prostate Cancer To Spread ( Since I published this I have received some feedback, which has included people asking if they should take statins to control their cholesterol levels. Statin drugs do help control cholesterol levels and might be a good alternative for some people, but all drugs come with side effects that need to be factored into the decision to take them. Statins are often thought of as being a drug without any side effects. Although many people to [...]

The Cholesterol In Your Diet Might Be Causing Your Prostate Cancer To Spread

Research performed at the University of Queensland has shown that a diet, which is high in cholesterol, might increase the spread of prostate cancer tumors to lymph nodes, lungs and bones. According to the UQ Diamantina Institute study leader Dr Michelle Hill this research highlighted why it is important for men with prostate cancer to choose a low-cholesterol diet. He said that a "High cholesterol doesn't change the size of the original prostate cancer tumor, but the effect on cancer spreading was shown to be significant." The research went beyond the normal studies that show that there is a correlation [...]