Genetics and Geonomics

/Genetics and Geonomics

Genetic Biomarker Predicts Peripheral Neuropathy Associated With Docetaxel Chemotherapy For Prostate Cancer

According to researchers at the H. Lee Moffitt Cancer Center & Research Institute, men with a mutation in their VAC14 gene are more susceptible to Docetaxil chemotherapy induced neuropathy and nerve pain. This debilitating side effect results from damage to the peripheral nerves and is felt by the man as weakness, numbness and pain most likely felt in the hands and feet. The Moffitt study was published online in the journal Clinical Cancer Research. The researchers analyzed the DNA of 623 men who had participated in a randomized phase 3 clinical trial that included docetaxel chemotherapy therapy. A total of [...]

New Markers To Make Better Treatment Decisions For Prostate Cancer

Making treatment decisions once you have been diagnosed with prostate cancer is difficult. Often, it is impossible to accurately and reliably be able to predict the eventual course of the cancer. Prostate cancer, besides being one of the slower growing cancers, is also one of the deadliest. So good, informed decisions are vital. The original standby prognostic markers for prostate cancer are a man’s PSA, the stage of the cancer and their Gleason grade. Given the poor quality of these markers, in the 2000s, more sensitive markers were developed, such as PSA density, % of positive cores, % of cancer [...]

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer Phase II Results

We know that prostate cancer is a heterogeneous disease, but most of our treatments are not based on the different molecular stratification exhibited by the disease. One of the differences we do recognize in the cancer is that some of the tumors have genetic DNA-repair defects. There has been evidence that in those cancers exhibiting these types of defects, a possible treatment is poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP) inhibition with the investigation treatment olaparib. Researchers conducted a phase 2 trial in which men with metastatic, castration-resistant prostate cancer (mCRPC) were treated with olaparib tablets at a dose of 400 mg [...]

By | March 31st, 2016|Clinical Trials & Research, genetics, olaparnib, PARP inhibitors|0 Comments

More From ASCO GU 2016 – ExoDx™ Prostate(IntelliScore): A More Precise, Genetically Informed Prostate Cancer Test from a Simple Urine Sample

The constant hope and conversation of late has surrounded what is referred to as a liquid biopsy. The hope and goal is to no longer need to have an invasive needle biopsy to diagnose and stage prostate cancer. Biopsies are not accurate because there are too many false negatives, they only evaluate the actual tissue sampled and do not take into consideration the un-sampled tissue (which can have a different type or stage of cancer present). They also are painful and worse expose men to the possibility of infections, some of which can be life threatening. We dream of finding [...]