[11C] choline PET/CT

//[11C] choline PET/CT

18F-Fluciclovine PET/CT Superior to 11C-Choline PET/CT for the Detection of a Prostate Cancer Relapse

We have all been ever increasingly aware of the weakness of our scanning technologies when it comes to both diagnosing prostate cancer and its recurrence. Given that about 1/3 of all primary treatments for prostate cancer will fail and the cancer will return it is vital that we improve our ability to detect prostate cancer recurrences earlier. In recent years, there have been a few improved contrasts developed that have increased scanning sensitivity. Two competing contrasts are a new PET compound (anti-3-(18)F-FACBC or (18)F-fluciclovine) and (11)C-choline. Researchers set out to compare these two contrasts for their sensitivity to detect a [...]

Decatur Memorial Hospital Now Offers A C-11 Choline PET CT To Men With Recurrent Prostate Cancer

According to a press release from the Decatur Memorial Hospital in Decatur Ill., after their having completed a clinical trial evaluating C-11 Choline PET CT and in men who have suffered a biochemical relapse of prostate cancer, they are now offering the C-11 Choline PET CT commercially. C-11 Choline uses an FDA approved tracer which, after injection, highlights more precisely than current tracers the location of prostate cancer tumors. This technology might allow men experiencing an early prostate cancer recurrence to “go after” these tumors before they spread even farther into the body. In the largest published study in the [...]

Comparing (18)F-FACBC (anti1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid) and (11)C-choline PET/CT in Prostate Cancer Relapse

There has been a lot of hype and confusion about what is the best contrast for prostate cancer PET/CT scans. The two newest contrasts; (18)F-FACBC (anti1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid) and (11)C-choline both have their supporters and their detractors. To try and evaluate the efficacy differences between these two contrasts in men who have suffered a bio-chemical recurrence after surgery researchers did a head to head evaluation of 100 consecutive men treated with surgery for prostate cancer and presenting with a rising PSA. All of the men had (11)C-choline and (18)F-FACBC PET/CTs performed within 1 week and were off hormonal therapy at the time [...]

Predicting the Long-Term Survival of Men with A Biochemical Recurrence Post-Surgery Who Are Hormone Naive Can Change How We Treat Them

Appearing in the European Journal of Nuclear Medicine and Molecular Imaging a recent study provides data on the long-term survival of men with a biochemical recurrence after failed surgery. In the study by Giovacchini et al. it was shown that a PET/CT scan (specifically a [11C] choline PET/CT) could predict the long-term survival of men who are hormone-naive (not yet started ADT) who had a biochemical failure (where biochemical failure was defined by a PSA level > 0.2 ng/ml post surgery). The study was a retrospective analysis of  302 men who were hormone-naive and who had been previously treated with a [...]