Understanding APC

Cognition and Hormone Therapy (ADT)

There have been numerous studies examining the how hormone deprivation (ADT), in the treatment of prostate cancer, has on a man’s cognition. There have been contradictor studies about this issue, however having had the experience and the honor of dealing with so many men with prostate cancer treated with androgen deprivation therapy (ADT), as well as my own personal experience, I must fall in line and agree with an online published study that shows that men on ADT are likely to experience cognitive impairment of some type. The study was small, as all of the other studies have been, followed [...]

A Prospective Evaluation Of The Health Related Quality of Life In Men Receiving Primary and Secondary Treatment for Prostate Cancer

Men with both high risk and intermediate risk prostate cancer will receive primary treatment and many also receive a second line of treatment. In a study that was designed to assess the impact of receiving both first and second line treatment on a man’s Health Related Quality of Life (HRQoL), researchers determined that men who received first line therapy suffered a decline in their HRQoL and those who also received a second line of therapy suffered an even greater decline. The study was a prospective cohort study, which was begun in 2007. The researchers evaluated the longitudinal patterns in HRQoL [...]

Understanding the Reality of the Side Effects from Early Chemotherapy

Ever since the research showing that men who are newly diagnosed with very aggressive prostate cancer have a significant life extension advantage if they move immediately to chemotherapy (with docetaxel) along with hormone therapy (ADT) there has been, what I can only describe as a paradigm shift in the clinical care of men with metastatic hormone-sensitive prostate cancer. However, many men are very afraid to have chemotherapy as there remains concerns about the toxicity (side effects) of the drug. A recent study, however, showed that the adverse events experienced by men who have early chemotherapy tends to be short-lived and [...]

A new Trend – Chemotherapy for Metastatic Castrate-Sensitive Prostate Cancer

Prostate cancer treatment will change as we incorporate new studies into our clinical practice. One of the major emerging new trends is the earlier use of chemotherapy with androgen therapy (ADT) in men, including men who are still hormone responsive. This changing trend comes from the results from there pivotal randomized phase III trials: GETUG15, CHAARTED and STAMPEDE. All three of these studies demonstrated a benefit in progression-free survival with the use of ADT along with docetaxel chemotherapy. However, only two of the studies demonstrated a clinically meaningful overall survival benefit (CHAARTED and STAMPEDE), whereas the GETUG15 study did not [...]

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